White Sox vs Red Sox Picks and Prediction – 4/20/2025

The Sunday MLB schedule will get started with a matchup between the Chicago White Sox and the Boston Red Sox from historic Fenway Park. Be ready for the baseball season with all of our MLB predictions. The White Sox (4-16) are in the midst of a six-game losing streak and own the worst record in the Eastern Conference. On Saturday, Chicago OF Luis Robert hit a two-run blast during a 4-3 road loss against Boston in ten innings. 

Twenty-five year old righty Sean Burke (1-3 7.56 ERA) is trying to find his way at the major league level for the White Sox. Last time out, Burke was knocked around for five runs and lasted just three plus innings during a 12-3 home loss versus the Athletics. 

The Boston Red Sox are riding a four-game winning streak and are two games off the pace in the AL East Division race. During yesterday’s home victory, 1B Triston Casas walked it off for Boston with a single that scored Alex Bregman. All-Star 3B Rafael Devers added a three-run shot for the Red Sox (12-10), who improved to 6-3 at home. 

Boston manager Alex Cora will turn to talented right-hander Tanner Houck (0-2 9.16 ERA) on Sunday. In his last start, Houck was shelled for 12 runs (11 ER) and recorded just seven outs during an ugly 16-1 road loss against Tampa Bay. 

Boston SP Lucas Giolito (hamstring) made a rehab start on Tuesday and could make his season debut later this week. Through 20 games, Chicago ranks 30th in OPS and 29th in runs scored. For the regular season, Boston ranks 10th in OPS and 7th in runs scored. Take the White Sox to win on the road. Final Score Prediction, Chicago White Sox win 6-4.