White Sox vs Red Sox Picks and Prediction – 4/18/2025

The Chicago White Sox open a three-game series on the road Friday versus the Boston Red Sox. Chicago is 4-13 following its 3-1 loss to the Athletics on Wednesday. The White Sox have won three straight, including the first two of a three-game series with the Athletics, which concludes Thursday. Chicago is last in the American League Central, 5 ½ games behind the first-place Detroit Tigers. Keep up to date with all the MLB action with our MLB previews.

Lenyn Sosa is batting .259 with 14 hits and an on-base percentage of .286 to lead Chicago in the three categories. Andrew Vaughn leads Chicago in home runs with two and in RBI with eight. Chicago is batting .200 with a .306 slugging percentage. On Friday, the Chicago White Sox will send Martin Perez to the mound. The left-hander is 1-0 with a 1.59 ERA, 18 Ks. and 8 BBs.

The Boston Red Sox improved to 10-10 following Wednesday’s 1-0 victory over the Tampa Bay Rays. David Hamilton’s third-inning home run was the only run of the game. Four Boston pitchers combined to strike out 13 Tampa Bay hitters. The Red Sox have won two straight and three of the last four. Boston trails first-place New York by two games in the American League East.

Alex Bregman is batting .321 to lead Boston and has team highs in home runs with four, RBI with 16, and hits with 25. Wilyer Abreu is the leader in on-base percentage at .427. Boston is batting .247 with a .382 slugging percentage. The Boston Red Sox have not announced their starting pitcher for Friday's first game of a three-game series at home versus Chicago.

Chicago will win behind a strong performance from its starting pitcher, but the play here is UNDER. The UNDER has cashed in seven of Chicago's last nine and five of Boston's last eight, including two of three last week versus the White Sox. Chicago starter Martin Perez has had three strong outings, allowing three runs across 17 innings with Chicago winning two of the three, including last Saturday over Boston, 3-2. Final Score Prediction: Chicago White Sox win but our best play is UNDER 4-2.