White Sox vs Orioles Picks and Prediction – 5/30/2025

The two worst teams in the American League will square off on Friday night, when the Chicago White Sox battle the Baltimore Orioles from Camden Yards. Be ready for the baseball season with all of our MLB predictions. The White Sox (18-38) have dropped 23 of their first 29 road games and are stuck at the bottom of the AL Central Division standings. On Wednesday, Chicago OF Andrew Benintendi fell a double short of the cycle and drove in four runs during a 9-4 road victory against the New York Mets. 

Twenty-five year old righty Sean Burke (3-5 4.33 ERA) will make his 11th start of the year for the White Sox. Last time out, Burke (6 IP) allowed one run and struck out six batters during a 4-1 home victory versus Texas. 

The Baltimore Orioles are eight games below .500 at home and have been the most disappointing team in the majors. On Wednesday, Baltimore batters went 3-for-17 with runners in scoring position and left ten men on base during a 6-4 home loss versus St. Louis. 2B Jackson Holliday went 3-for-5 with an RBI for the Orioles (19-36), who fell to 9-17 at home.

The Orioles will counter with thirty-one year old righty Zach Eflin (3-2 5.40 ERA) in the series opener. Baltimore has dropped Eflin’s previous two starts and he has surrendered 13 runs across his last ten plus frames. 

Baltimore OF Tyler O’Neill (shoulder) has resumed baseball activities and will begin a rehab assignment soon. Through 56 games, Chicago ranks 28th in OPS and 26th in runs scored. For the season, Baltimore ranks 19th in OPS and 24th in runs scored. Take the over. Final Score Prediction, Baltimore Orioles win 8-4.