Cubs vs Cardinals Picks and Prediction – 6/25/2025

The storied rivalry continues as the Chicago Cubs (46–32) visit the St. Louis Cardinals (43–36) for Game 3 of a four-game set. Wednesday’s pitching duel pairs Cubs lefty Matthew Boyd (6–3, 2.84 ERA) against Cards right-hander Andre Pallante (5–3, 4.48 ERA). With both teams eyeing a divisional boost, this midweek clash carries significant weight under the Busch Stadium lights. Get in on all the baseball action with our free MLB picks.

Matthew Boyd has been the model of consistency this season—owning a 6–3 record with 10 quality starts in 15 outings and a 1.14 WHIP. He's been especially tough on the road, where Chicago boasts a 22–17 record when he's in the rotation . Offensively, the Cubs are firing on all cylinders with a dynamic outfield of Ian Happ, Kyle Tucker, Seiya Suzuki, and Pete Crow‑Armstrong—a group leading the rivalry in home runs and slugging. While the bullpen has stumbled, Chicago’s bats and Boyd’s control make them a dangerous foe.

Andre Pallante looks to capitalize on a 3-game winning streak, sporting a 5–3 record with a 4.48 ERA and six quality starts. He's been even better at home (3–1, 4.34 ERA), where St. Louis' elite defense—from top in Outs Above Average—can help erase mistakes. Offensively, the Cardinals have heated up, winning four of their last five, but continue to rely on role players like Alec Burleson and accelerating slumps from Walker and Nootbaar.

Expect a low-to-mid scoring tug-of-war. Boyd’s road dominance and Chicago’s lineup give the Cubs a slight edge, yet Pallante’s recent form and St. Louis’ home defense keep this tight. Ultimately, we trust the arm of Boyd and the Cub offense has enough in their bag to take this one. We think the Chicago Cubs emerge victorious by a score of 4-3.