Cubs vs Cardinals Picks and Prediction – 6/24/2025

The storied rivalry returns under the summer sky as the Chicago Cubs (46–31) travel to face the St. Louis Cardinals (42–36) at Busch Stadium. With divisional positioning on the line and both teams eager to assert dominance, tonight’s rubber match features right-handers Jameson Taillon for Chicago and Erick Fedde for St. Louis in a crucial midweek contest. Get in on the action with our MLB picks.

Taillon has bounced back from a recent rough outing, holding a solid 7–4 record with a 3.84 ERA. While not overpowering, he’s reliable and effective when pounding the zone. Offensively, the Cubs remain potent, featuring top contributors like Kyle Tucker (81 hits, 46 RBI), Nico Hoerner, and Pete Crow‑Armstrong with 160 combined hits and 92 RBI—plus Seiya Suzuki’s dynamic bat. However, Chicago’s pitching staff stumbled in their last game, giving up 14 runs, and they’ll need bounce-back effort from starters and relievers alike.

Fedde (3–6, 3.54 ERA) has shown glimpses of steadiness, limiting hard contact and benefiting from the league’s best defense in Outs Above Average. At the plate, the Cards have seen uneven production, exacerbated by Ivan Herrera’s IL stint, but Willson Contreras and Brendan Donovan have stepped up when needed. A recent 5–1 run has energized the team and pulled them just 4½ games behind the Cubs in the NL Central.

This is a close matchup, and is lined as such. With a divisional matchup things get even more unpredictable. We will look toward the momentum of the Cardinals and back them to win a tight contest. We like the St. Louis Cardinals to win this one by a score of 5-4.