Cubs vs Padres Picks and Prediction – 4/16/2025

The Chicago Cubs will be on the road again Tuesday with game two of three in San Diego against the Padres. Chicago is playing well this season coming into this matchup with eleven wins and seven losses on the year having won three of the last five including two in a row after a 2 run victory on the road against Los Angeles last time out. Offensively the Cubs have a .2516 batting average as they have scored 116 runs on 161 total hits here the Chicago power has shined this season as well with 25 home runs and they .439 team slugging percentage. Stay up to date with our MLB Picks.

 Kyle Tucker leads the Chicago offense this season with a .324 batting average, five home runs, and eighteen RBI's. Seiya Suzuki has a .292 batting average and Nico Hoerner has chipped in heavily with a .291 batting average despite playing in just fourteen games this season.

The San Diego Padres stay home Tuesday as the best team in baseball with thirteen wins and three losses overall riding a 4 game-winning streak following a six run victory against Colorado in their last outing. Offensively San Diego has a .283 batting average having scored 73 runs on 148 hits. The San Diego pitching has been elite as well with a 2.68 team ERA this season.

Fernando Tatis Jr. leads the way for the San Diego offense this season with the .351 batting average and four home runs on the year. Manny Machado has a .317 batting average and Xander Bogaerts has a .304 batting average. Jackson Merrill leads San Diego this season with ten RB's despite playing in only 10 games this season.

The San Diego Padres are the better team in this matchup, and it will show from the opening pitches on Tuesday. Look for San Diego to control this game on both sides of the ball as they will continue their tear. Take the Padres Tuesday night to do the job as they get the win at home against a good Chicago team. Final Score Prediction, San Diego Padres win 6-2.