Cubs vs Padres Picks and Prediction – 4/16/2025

The Chicago Cubs will conclude a three-game series on the road Wednesday versus the San Diego Padres. Chicago is 11-8 and first in the National League Central, 1 ½ games ahead of the St. Louis Cardinals and Cincinnati Reds. Chicago lost to San Diego 10-4 on Monday in the opening game of the series, snapping a two-game winning streak for the Cubs. Keep up to date with all the MLB action with our expert MLB picks.

Michael Busch is batting .310 to lead Chicago. Kyle Tucker has five home runs, 18 RBI, 23 hits, and an on-base percentage of .429 to lead Chicago in the four categories. Chicago is batting .256 with a slugging percentage of .439. On Wednesday, the Chicago Cubs will send Matthew Boyd to the mound. The left-hander is 1-1 with a 1.59 ERA, 17 Ks, and 7 BBs.

The San Diego Padres improved to 14-3 following Monday’s six-run victory over Chicago. Fernando Tatis Jr hit a pair of home runs and, on a wild pitch, scored the run to put San Diego ahead for good. San Diego is 11-0 at home to start the season and has won each of its last five overall. The Padres lead the National League West by 1 ½ games over the San Francisco Giants.

Fernando Tatis Jr is batting .361 with six home runs, 12 RBI, 22 hits, and an on-base percentage of .429 to lead San Diego in each of the five stats. Jackson Merrill is second in home runs with three and tied for second with Gavin Sheets in RBI with 10 apiece. On Wednesday, the San Diego Padres will send Nick Pivetta to the mound. The right-hander is 2-1 with a 1.59 ERA, 18 Ks, and 4 BBs.

Chicago has won nine of its last 13 and defeated San Diego last time the two starting pitchers for Wednesday were on the mound facing one another 10 days ago. Chicago starter Matthew Boyd held San Diego to no runs across six innings in a 7-1 win a week ago this past Saturday. San Diego starter Nick Pivetta gave up three runs on six hits across just three innings when losing to Chicago in the same game Boyd pitched. Final Score Prediction: Chicago Cubs win 5-2.