Cubs vs Padres Picks and Prediction – 4/15/2025

The Chicago Cubs open a three-game series on the road Monday versus the San Diego Padres. Chicago improved to 10-7 following Saturday’s 16-0 rout of the Los Angeles Dodgers, snapping a two-game losing streak by the Cubs. Chicago concludes its three-game series with Los Angeles on Sunday. The Cubs are first in the National League Central, one game ahead of the Milwaukee Brewers. Keep up to date with all the MLB action with our expert MLB picks.

Kyle Tucker is batting .328 with five home runs, 18 RBI, 22 hits, and an on-base percentage of .451 to lead Chicago in each of the five categories. Dansby Swanson and Seiya Suzuki are second in home runs with four apiece. On Monday, the Chicago Cubs will send Jameson Taillon to the mound. The right-hander is 1-1 with a 6.06 ERA, 14 Ks, and 4 BBs.

The San Diego Padres improved to 12-3 following Saturday’s 2-0 victory over the Colorado Rockies. Fernando Tatis Jr and Jason Heyward each homered for the Padres. San Diego has won three straight and five of the last six. The Padres lead the National League West by 1 ½ games over the San Francisco Giants and the Los Angeles Dodgers.

Fernando Tatis Jr is batting .365 with four home runs, 19 hits, and an on-base percentage of .433 to lead San Diego in each of the four categories. Jackson Merrill is the leader in RBI with 10. San Diego is batting .279 with a .420 slugging percentage. On Monday, the Padres will send Dylan Cease to the mound. The right-hander is 1-1 with a 7.98 ERA, 18 Ks, and 6 BBs.

San Diego will win on Monday when hosting Chicago, but the play here is OVER. The OVER has cashed in six of Chicago's last seven and five of San Diego's last seven. Chicago starter Jameson Taillon has struggled in each of three outings, allowing 11 runs on 18 hits across 16.1 innings. San Diego starter Dylan Cease gave up nine runs on nine hits across four innings last time out. Final Score Prediction: San Diego Padres win but our best play is OVER 8-5.