Cubs vs Astros Picks and Prediction – 6/28/2025

This Saturday, Colin Rea takes the ball for the Cubs as they aim to bounce back against Lance McCullers and the Astros at Minute Maid Park. Get our free MLB Picks all season long! Houston took the series opener 7-4, continuing their recent surge, while Chicago looks to snap out of a frustrating stretch against top-tier competition.

Rea will need to keep Houston’s dangerous bats in check by attacking the zone early and avoiding long innings. The Cubs’ bullpen has logged heavy use recently, making it crucial for Rea to eat innings and limit damage. Offensively, Chicago will lean on timely hitting to keep pace with Houston’s firepower.

McCullers, returning from a long layoff, will look to settle in quickly. His ability to locate his fastball and mix in breaking pitches will be key to keeping Chicago off-balance. The Astros’ lineup has remained one of the league’s most consistent, and they’ve shown a knack for capitalizing on mistakes.

Both sides are postseason contenders, and this matchup feels like a potential October preview. With two teams loaded with experience and power, the margins will be razor thin and decided by execution in key moments.

Expect a hard fought battle with postseason energy. Both pitchers will aim for control early, but Houston’s deeper lineup and recent momentum give them the edge. If McCullers finds rhythm and the bullpen holds, the Astros should seal another tight win at home. Final Score Prediction, Houston Astros win 6-4.