Cubs vs Astros Picks and Prediction – 6/28/2025

The Cubs are set to face the Astros from Houston on Friday. The game is being played at Daikin Park and has a first pitch time of 8:10 PM EST and is being aired on local channels. Be ready for the baseball season with all of our MLB free picks.

The Cubs last 5 games have seen them post an 2-3 mark. The last game was a 3-0 win over the Cardinals. The win moved Chicago to a record of 48-33 on the year.

Chicago is coming here with a .255 average and 708 hits. The Cubs have scored 434 runs while getting a decent 118 homers. The Cubs have posted a 3.90 ERA and a 1.26 WHIP. The opponents are hitting at a clip of only .250 on the season against the Cubs pitching staff.

The Astros are coming to this game here with an impressive 4-1 mark in their last 5 games. The last game for the Astros was a 2-1 win over the Phillies. The win moved the Astros to a record of 48-33 on the year overall. 

Houston is coming here with a .256 average with 684 hits. Still, the Astros have scored a total of 336 runs with 86 homers cranked out. Houston has allowed the opponents to hit at a clip of only .219, but has posted a 3.43 ERA and a 1.15 WHIP on the year.

This is the first game of this series that is slated to be an epic matchup as both of these teams are playing some great baseball this year. However, it will come down to the Cubs power hitting versus the Astros pitching and that is what this game comes down to. The starting pitching, though, in this game we like the Cubs starter, Horton, to help secure the win for Chicago with his better depth in the game, but also his better overall record and ERA. Final Score Prediction, Chicago Cubs win 3-2.