Cubs vs Astros Picks and Prediction – 6/29/2025

The Chicago Cubs conclude a three-game series on the road Sunday versus the Houston Astros. Chicago is 48-34 following Friday’s 7-4 loss to the Astros in the opening game of the series. The Cubs have lost four of the last six, with only a pair of wins over St. Louis. Chicago leads the National League Central by two games over the Milwaukee Brewers. Keep up to date with all the MLB action with our expert MLB picks.

Nico Hoerner is batting .294 with 88 hits to lead Chicago in both categories. Seiya Suzuki is the leader in home runs with 21 and RBI with 67, while Kyle Tucker has a team-high in on-base percentage at .391. Chicago is batting .255 with a .444 slugging percentage. On Sunday, Chicago will send Jameson Taillon to the mound. The right-hander is 7-5 with a 4.47 ERA, 70 Ks, and 19 BBs.

The Houston Astros improved to 49-33 following Friday’s three-run victory over the Chicago Cubs. Cam Smith, playing in his first game against Chicago since being traded, and Yainer Diaz each hit three-run homers for the Astros, while Brandon Walter pitched six strong innings. Houston has won five straight, and the Astros lead the American League West by 6 ½ games over the Seattle Mariners.

Jeremy Pena is batting .322 with 102 hits and an on-base percentage of .378 to lead Houston in the three categories. Isaac Paredes leads in home runs with 16 and in RBI with 45. Houston is batting .256 with a .400 slugging percentage. On Sunday, the Houston Astros will send Framber Valdez to the mound. The left-hander is 8-4 with a 2.88 ERA, 102 Ks, and 37 BBs.

Houston has won each of its last five, and the Astros have won nine straight playing at home. Chicago starter Jameson Taillon was roughed up last time out, allowing three runs on eight hits across just 4.0 innings. Houston starter Framber Valdez has had five consecutive solid outings, allowing seven runs on 23 hits across 34 innings, with Houston winning each of the five. Final Score Prediction: Houston Astros win 5-2.