Cubs vs Reds Picks and Prediction – 5/25/2025

The Great American Ball Park will be the scene for a Sunday afternoon NL Central Division showdown between the Chicago Cubs and the Cincinnati Reds. Be ready for the baseball season with all of our MLB predictions. The Cubs (31-21) have won 16 of their first 27 road games and hold a two-game lead over St. Louis for first place. On Saturday, Chicago batters went 0-for-9 with runners in scoring position and left seven men on base during a 6-4 road loss against Cincinnati. 

Twenty-five year old righty Ben Brown (3-3 5.44 ERA) will take the mound for the Cubs in this matchup. In his last start, Brown (4.2 IP) gave up six runs and struck out eight batters during an 8-7 road loss against Miami. 

The Cincinnati Reds are a game above .500 at home and are 5.5 games out of first place. During yesterday’s home victory. All-Star SS Elly De La Cruz went 2-for-4 with a home run and four RBI’s to power the Cincinnati offense. SP Andrew Abbott (4-0) allowed one run across five plus frames to earn the win for the Reds (26-27). 

Twenty-seven year old southpaw Nick Lodolo (4-4 3.22 ERA) has been quietly pitching well for the Reds. Last time out, Lodolo (6 IP) allowed one run and fanned seven batters during a 7-1 road triumph against Pittsburgh. 

Chicago SP Shota Imanaga (hamstring) will throw a bullpen session on Tuesday and is expected to rejoin the rotation next month. Through 52 games, Chicago ranks 3rd in OPS and 1st in runs scored. For the season, Cincinnati ranks 12th in OPS and 9th in runs scored. Take the Cubs to win on the road. Final Score Prediction, Chicago Cubs win 5-4.