Cubs vs Diamondbacks Picks and Prediction – 3/28/2025

The Arizona Diamondbacks will host the Chicago Cubs for their season opener at Chase Field on Thursday, March 27, 2025, with the first pitch scheduled for 10:10 PM ET. The game will be broadcast on ARID and MARQ. ​Get in on all the baseball action with our free MLB picks.

The Cubs began their 2025 season with two losses against the Los Angeles Dodgers in the Tokyo Series, falling 4-1 and 6-3. Second baseman Nico Hoerner, recovering from offseason surgery on a right flexor tendon tear, did not travel to Japan and his availability for Opening Day remains uncertain. In his absence, options like Jon Berti, Vidal Bruján, and Gage Workman may fill the position. ​Chicago seems at a bit of a crossroads in their current state. The Cubs have a decent team, but do not seem to have the horses for a title run.

The Diamondbacks enter the season with heightened expectations after significant offseason moves, including signing right-hander Corbin Burnes to a $210 million contract. They aim to challenge the Los Angeles Dodgers in the NL West. Zac Gallen is slated as the starting pitcher for the opener. ​Arizona will try to recapture the magic of their World Series appearance two seasons ago.

With not much information to go on, other than the Cubs losing to a mighty opponent in their first series, we will look to the starting pitcher we trust. Pitches may be limited in the opening day games for each starter, but we will still back Zac Gallen as he was one of our most reliable targets last season. Roll the dice on the D-Backs and back them to win this one by a score of 4-2.