Red Sox vs Rays Picks and Prediction – 4/16/2025

The Boston Red Sox remain in Tampa Bay on Wednesday to take on the Rays. The Red Sox are averaging 4.3 runs scored per game with 8.6 hits. Boston has won four of their last ten games and carry a losing road record. The Red Sox allowed 16 runs in their loss to the Rays on Monday. Stay up to date with our expert's MLB Picks. 

Sean Newcomb will make his 4th start on the mound for the Boston Red Sox. Newcomb is 0-2 on the season with 12.2 innings pitched. Newcomb has allowed 15 strikeouts and carries a 4.97 ERA. Newcomb hasn't pitched past the 4th inning yet this season. 

The Tampa Bay Rays have also won four of their last ten games. The Rays are averaging 4.8 runs scored per game with 9.1 hits. Tampa Bay had a 9 run inning on Monday when they beat Boston 16-1. The Rays play their best baseball at home. 

Zack Littell will make his 4th start on the bump for the Tampa Bay Rays. Littell is 0-3 on the season with 17 innings pitched. Littell has 14 strikeouts and carries a 6.88 ERA. Littell pitched 4 innings in his last start allowing 8 hits and 7 earned runs. 

Both Zack Littell and Sean Newcomb are ready to get into the win column. Both Littell and Newcomb both carry ERA's over 4.00. Expect the bats to be swinging and the bullpens to be active. The value is in the total. Final Score Prediction, Tampa Bay Rays win, but the play is on the over 9-5.