Red Sox vs Giants Picks and Prediction – 6/22/2025

By: Jeremy O’Quinn |

Last Updated: 06/21/2025 at 8:00 PM ET

Boston Red Sox at San Francisco Giants 06/22/25 - MLB Picks & Predictions
Game Start: 6/22/2025, 8:05 PM UTC
Latest Odds: SFG -157 ; O/U 7.8

Red Sox vs Giants Prediction

The Boston Red Sox will be returning to Oracle Park on Sunday, where they will take on the San Francisco Giants. Get the rest of our free MLB picks here! The Red Sox have put together a record of 40-37 which places them fourth in the AL East. The Red Sox have now won 8 of their last 10 games, as they are coming off a 7-5 victory over the Giants. Lucas Giolito will be Boston’s starting pitcher on Sunday, he’s sitting with a 4.72 ERA to go along with a 3-1 record. The Red Sox are recording 5.0 runs per game, while allowing 4.8 runs defensively.

The San Francisco Giants currently sit second in the jam packed NL West, entering this game with a 42-34 record. San Francisco has now lost 5 of their last 6 games, most recently suffering a 7-5 loss against Boston. Robbie Ray will be the Giants’ starting pitcher in this game, he’s posted a 2.68 ERA to go along with his 8-2 record. San Francisco is putting up 7.6 hits and 4.2 runs per game while batting .232. The Giants’ bullpen has been great through 7 games, they’re allowing 7.6 hits and 3.7 runs per game.

Red Sox vs Giants Pick Analysis

The Red Sox look to keep this hot stretch going, while San Francisco is desperate to break out of this slump. Ray has been excellent this season, expect his play to help lead the Giants to the much needed win. Final score prediction, Giants win on the run line 5-3.

Our Free MLB Pick for San Francisco Giants vs Boston Red Sox

San Francisco Giants: -1.5