Red Sox vs Giants Picks and Prediction – 6/21/2025

By: Kim Smith |

Last Updated: 06/19/2025 at 11:18 PM ET

Boston Red Sox at San Francisco Giants 06/20/25 - MLB Picks & Predictions
Game Start: 6/21/2025, 2:15 AM UTC
Latest Odds: SFG -130 ; O/U 7.5

Red Sox vs Giants Prediction

The Red Sox are set to face the Giants from San Francisco on Friday. The game is being played at Oracle Park and has a first pitch time of 10:15 PM EST and is being aired on local networks. Be ready for the baseball season with all of our MLB free picks.

The Giants last 5 games have seen them post a 1-4 mark. The last game was a 2-1 win over the Guardians. The win moved San Francisco to a record of 42-33 on the year.

San Francisco is coming here with a .233 average and 567 hits. The Giants have scored 313 runs while getting a decent clip of 71 homers. The Giants have posted a 3.26 ERA and a 1.22 WHIP. The opponents are hitting at a clip of only .231 on the season against the Giants pitching staff.

The Red Sox are coming to this game here with an middle of the road 4-1 mark in their last 5 games. The last game for the Red Sox was a 3-1 win over the Mariners. The win moved the Red Sox to a record of 39-37 on the year overall. 

Boston is coming here with a .248 average with 651 hits. Still, the Red Sox have scored a total of 358 runs with 92 homers cranked out. Boston has allowed the opponents to hit at a clip of only .249, but has posted a 3.93 ERA and a 1.31 WHIP on the year.

Red Sox vs Giants Pick Analysis

The game here is one that has potential to be interesting as both of these teams have been fairly even on the records this year. However, the Red Sox are coming in hitting better, but when compared to the Giants pitching Boston has looked horrible. Look for the Giants, though, to come out on to the field in this game and have a better small ball game that is going to help the team in getting the win here. Final Score Prediction, San Francisco Giants win 3-1.

Our Free MLB Pick for San Francisco Giants vs Boston Red Sox

San Francisco Giants -130