Red Sox vs Yankees Picks and Prediction – 6/6/2025

By: Eddie Kline |

Last Updated: 06/05/2025 at 10:40 PM ET

Boston Red Sox at New York Yankees 06/06/25 - MLB Picks & Predictions
Game Start: 6/6/2025, 11:05 PM UTC
Latest Odds: NYY -170 ; O/U 9

Red Sox vs Yankees Prediction

AL East Division rivals will square off on Friday night, when the Boston Red Sox travel to the Bronx to take on the New York Yankees. Be ready for the baseball season with all of our MLB predictions. The Red Sox (30-34) have dropped seven of their previous ten games and are nine games out of first place. On Wednesday, OF Ceddanne Rafaela walked it off with a two-run blast to give Boston a much needed 11-9 home victory versus Los Angeles. 

Thirty year old right-hander Walker Buehler (4-3 4.44 ERA) will take the mound for the Red Sox in this matchup. Boston has dropped Buehler’s previous two starts and he has surrendered seven runs over his last ten plus innings. 

The New York Yankees have won 20 of their first 30 home games and are 5.5 games clear of two teams for the top spot in the division. Last night, OF Cody Bellinger hit a two-run bomb and added an RBI single to power New York to a 4-0 home victory versus Cleveland. SP Max Fried (8-1) fanned seven batters and lasted six innings to earn the win for the Yankees, who improved to 38-23 overall.

The Yankees will counter with twenty-five year old righty Will Warren (3-3 5.19 ERA) in the series opener. Last time out, Warren was roughed up for seven runs and recorded just four outs during an ugly 18-2 road loss against the Los Angeles Dodgers. 

Red Sox vs Yankees Pick Analysis

New York DH Giancarlo Stanton (elbows) is targeting the middle of this month to make his season debut. Through 64 games, Boston ranks 5th in OPS and 6th in runs scored. For the season, New York ranks 2nd in OPS and 3rd in runs scored. Take the Red Sox to win on the road. Final Score Prediction, Boston Red Sox win 6-4.

Our Free MLB Pick for New York Yankees vs Boston Red Sox

Boston Red Sox +150