Red Sox vs Angels Picks and Prediction – 6/25/2025

By: Eddie Kline |

Last Updated: 06/25/2025 at 12:39 AM ET

Boston Red Sox at Los Angeles Angels 06/25/25 - MLB Picks & Predictions
Game Start: 6/25/2025, 8:07 PM UTC
Latest Odds: LAA -120 ; O/U 9

Red Sox vs Angels Prediction

In Wednesday afternoon MLB action, the Boston Red Sox and the Los Angeles Angels will conclude their series from Angel Stadium. Be ready for the baseball season with all of our MLB predictions. The Red Sox (40-41) are looking to snap a four-game losing streak and are 6.5 games off the pace in the AL East Division race. Last night, Boston IF Marcelo Mayer went 3-for-4 with a run scored and an RBI during a 3-2 road loss in ten innings. 

Twenty-five year old righty Richard Fitts (0-3 4.71 ERA) will take the mound for the Red Sox in this matchup. Last time out, Fitts was roughed up for six runs (5 ER) and recorded just three outs during a 7-6 home loss versus Los Angeles. 

The Los Angeles Angels have split their first 36 home games and are 6.5 games out of first place in the AL West Division. On Tuesday, rookie 2B Christian Moore sent the Los Angeles fans home happy with a two-run walkoff blast. Moore added a solo shot to provide the offense for the Angels, who improved to 39-40 overall. 

Los Angeles manager Ron Washington will give the nod to left-hander Yusei Kikuchi (2-6 3.01 ERA) on Wednesday. In his last start, Kikuchi (7 IP) allowed two runs and struck out nine batters during a 3-2 home victory versus Houston. 

Red Sox vs Angels Pick Analysis

Los Angeles closer Kenley Jansen exited Monday’s game with neck/pectoral cramping and is listed as day-to-day. Through 81 games, Boston ranks 7th in OPS and 6th in runs scored. For the season, Los Angeles ranks 23rd in OPS and 19th in runs scored. Take the Angels to win at home. Final Score Prediction, Los Angeles Angels win 6-2.

Our Free MLB Pick for Los Angeles Angels vs Boston Red Sox

Los Angeles Angels -120