Red Sox vs Guardians Picks and Prediction – 4/26/2025

The Boston Red Sox will be in Cleveland early Saturday afternoon for game one of a doubleheader against the Cleveland Guardians. Boston plays game one of the doubleheader on Saturday, following Friday night's game being postponed due to weather. Boston has fourteen wins on the year but come into this game having lost three of the last five overall including two in a row including a one-run loss to Seattle in its last outing. Stay in the action with our MLB Picks.

Alex Bregman leads the Boston offense this season with a .320 batting average and 21 RBI's overall. Trevor Story has a .297 batting average and is one of two players this season with five home runs to lead the team. Jaron Duran has a .250 batting average and Wilyer Abreu has a .271 batting average through 26 games played this season.

The Cleveland Guardians come into Saturday with 14 wins and 10 losses on the year following a four run loss to the New York Yankees in their last outing to end a lengthy winning streak. Offensively Cleveland has a .235 batting average having scored 96 runs on 183 hits this season. The Cleveland pitching has been solid enough this season as well with a 3.94 ERA on the year.

Steven Kwan leads the Cleveland offense this season with a .337 batting average. Carlos Santana has a .204 batting average and Jose Ramirez has a .265 batting average. Gabriel Arias has a .270 batting average across 27 games played. Kyle Manzardo supplies the power for Cleveland leading the way with seven home runs and eighteen RBI's this year.

Cleveland is at home in this game and that will give the Guardians the edge. Look for the Guardians to do the work leading to the win in game 1 of the double header. Take Cleveland to do the job Saturday leading to the game 1 win. Final Score Prediction, Cleveland Guardians win 5-1.