Red Sox vs Guardians Picks and Prediction – 4/25/2025

The Boston Red Sox open a three-game series on the road Friday versus the Cleveland Guardians. Boston is 14-12 following an 8-5 loss to the Seattle Mariners in the second game of the three-game series, which concludes on Thursday. Boston has won six of the last eight, and the Red Sox are second in the American League East, 1 ½ games behind first-place New York. Keep up to date with all the MLB action with our expert MLB picks.

Alex Bregman is batting .310 to lead Boston and has team highs in RBI with 19 and hits with 31. Trevor Story is the leader in home runs with five, while Kristian Campbell is the leader in on-base percentage at .406. Boston is batting .247 with a .399 slugging percentage. On Friday, Boston will send Tanner Houck to the mound. The right-hander is 0-2 with a 7.66 ERA, 18 Ks, and 11 BBs.

The Cleveland Guardians dropped to 14-10 following a 5-1 loss to the New York Yankees on Wednesday in the final game of a three-game series, in which Cleveland won each of the first two. The loss on Wednesday snapped a five-game winning streak for the Guardians. Cleveland is second in the American League Central, a half-game behind first-place Detroit.

Steven Kwan is batting .337 with 32 hits and an on-base percentage of .394 to lead Cleveland in the three categories. Kyle Manzardo is the leader in home runs with seven and in RBI with 18. Cleveland is batting .235 with a .386 slugging percentage. On Friday, Cleveland will send Ben Lively to the mound. The right-hander is 1-2 with a 3.86 ERA, 19 Ks, and 8 BBs.

Cleveland has won five of its last six, and the Guardians are 8-4 over the last 12 versus an opponent from the American League. Boston starter Tanner Houck has struggled in two consecutive outings, allowing 11 runs on 13 hits across 8.1 innings. Cleveland starter Ben Lively is coming off a strong outing, in which the right-hander allowed no runs on five hits across 5.1 innings. Final Score Prediction: Cleveland Guardians win 6-3.