Red Sox vs White Sox Picks and Prediction – 4/12/2025

The Boston Red Sox play the second game of a three-game series on the road Saturday versus the Chicago White Sox. Boston is 7-7 and one game behind first-place co-leaders New York and Toronto in the American League East. Boston defeated Toronto 4-3 in 10 innings on Thursday to avoid being swept in a four-game series after losing the first three to the Blue Jays. Keep up to date with all the MLB action with our expert MLB picks.

Wilyer Abreu is batting .350 with three home runs and an on-base percentage of .480 to lead Boston in each of the three categories. Alex Bregman is the leader in RBI with 12 and hits with 17. Boston is batting .255 with a slugging percentage of .385. On Saturday, Boston will send Richard Fitts to the mound. The right-hander is 0-2 with a 4.50 ERA, 8 Ks, and 4 BBs.

The Chicago White Sox dropped to 2-10 following a 6-1 loss to the Cleveland Guardians on Thursday. Chicago was swept in its three-game series with Cleveland and before that was swept in a three-game series by Detroit. The White Sox have lost eight straight and 10 of the last 11. Chicago is last in the American League Central, five games behind first-place Detroit.

Andrew Benintendi is batting .290 with two home runs, six RBI, nine hits, and an on-base percentage of .333 to lead Chicago in each of the five categories, but he is out injured. Chicago has a team batting average of .199 and a slugging percentage of .305. On Saturday, the Chicago White Sox will send Martin Perez to the mound. The left-hander is 1-0 with a 0.73 ERA, 13 Ks, and 5 BBs.

Chicago will win at home on Saturday, but the play here is UNDER. The UNDER has cashed in nine of Boston's last 12 on the road, four of Chicago's last five overall, and 13 of Chicago's last 20 head-to-head versus the Red Sox. Boston starter Richard Fitts has allowed six runs across 12 innings in two outings. Chicago starter Martin Perez has allowed just one run across 12.1 innings, with Chicago winning one and losing one. Final Score Prediction, Chicago White Sox win but our best play is UNDER 4-2.