Orioles vs Nationals Picks and Prediction – 4/23/2025

The Baltimore Orioles play the second game of a three-game series on the road Wednesday versus the Washington Nationals. Baltimore is 9-12 and was off on Monday. The Orioles lost to the Cincinnati Reds 24-2 on Sunday, dropping two out of three in their series with Cincinnati. Baltimore is 4th in the American League East, four games behind the first-place New York Yankees. Keep up to date with all the MLB action with our MLB picks.

Cedric Mullins is batting .284 with six home runs, 19 RBI, 19 hits, and an on-base percentage of .429 to lead Baltimore in the five categories. Adley Rutschman and Jordan Westburg are second in home runs with four each. Baltimore is batting .232 with a .418 slugging percentage. On Wednesday, Baltimore will send Tomoyuki Sugano to the mound. The right-hander is 2-1 with a 3.43 ERA, 8 Ks, and 5 BBs.

The Washington Nationals are 9-13 following a 3-1 loss on Sunday in the second half of a doubleheader after winning the first game over the Colorado Rockies 3-2. The Nationals won two out of three versus Colorado. Washington was off on Monday. The Nationals are fourth in the National League East, 6 ½ games behind the first-place New York Mets.

Keibert Ruiz is batting .306 to lead Washington, and James Wood is the leader in home runs with seven. Nathaniel Lowe is the leader in RBI was 17, hits with 23, and on-base percentage with .375. Washington is batting .229 with a .368 slugging percentage. On Wednesday, the Nationals will send Trevor Williams to the mound. The right-hander is 1-2 with a 5.95 ERA, 16 Ks, and 6 BBs.

Baltimore will win on the road Wednesday when visiting Washington, but the play here is OVER. The OVER has cashed in four of Baltimore's last five and 11 of Washington's last 13 at home. Baltimore starter Tomoyuki Sugano was hit hard in each of the two outings, allowing five runs on 13 hits across 11.2 innings. Washington starter Trevor Williams gave up seven runs on 11 hits across the last 9.2 innings in his most recent two outings. Final Score Prediction: Baltimore Orioles win, but our best play is OVER 8-6.