Orioles vs Mariners Picks and Prediction – 6/5/2025

The Orioles and Mariners square off at T-Mobile Park Wednesday night at 7:40 PM EST in game two of the series. Baltimore sits at 22-36 and just swept the White Sox, taking the last game 3-2. Seattle is 32-26 and edged Minnesota 2-1 in a tight win. It’ll be lefty Cade Povich (1-4, 5.29 ERA) for Baltimore against righty Emerson Hancock (2-2, 5.64 ERA) for Seattle. Elevate your MLB game with our top-notch MLB picks.

Baltimore has quietly won three straight, showing some life after a rough season so far. That momentum came against the lowly White Sox, but it still counts. The offense has relied on Cedric Mullins, who leads with 10 homers and 31 RBIs, while Ryan O’Hearn is hitting a solid .329. Still, run production has been a struggle — just 222 runs scored and a team average of .237 shows why this lineup ranks near the bottom in the AL.

On the mound, the Orioles have been a mess. The team ERA sits at a brutal 5.27 with a 1.46 WHIP. Povich has struggled with command, giving up 20 walks and 9 home runs in 51 innings. The bullpen hasn’t fared much better. Baltimore also comes in banged up with Tyler O’Neill, Gary Sanchez, and Jordan Westburg all on the IL, making it even harder to piece together consistent innings on either side of the ball.

Seattle comes in with back-to-back wins over Minnesota and leads the AL West. Despite recent inconsistency, they’ve shown a knack for grinding out close games, and that’s made a difference in tight standings. Cal Raleigh is mashing with 23 homers and 45 RBIs, while J.P. Crawford has been getting on base at a .388 clip. The Mariners have hit 79 homers as a team and scored 263 runs, 41 more than Baltimore.

Pitching and defense have been Seattle’s strengths. The team ERA is 3.86, and the WHIP is a solid 1.33. Hancock isn’t dominant, but he has the easier task against an Orioles team struggling to hit. The Mariners also benefit from home-field advantage, where they’re 16-14. Even with a few arms on the IL, including Trent Thornton and Logan Gilbert, Seattle has more stability on the mound and in the field.

The Mariners have the clear edge both offensively and defensively. Seattle pitching is much better, and the Mariners have shown they can produce in late-game situations. The Orioles' recent wins came against a far weaker team, and the injury report doesn't help. With Seattle averaging more runs and allowing far fewer, the gap between these clubs is wide right now. Final Score Prediction: Seattle Mariners win 6-3.