Orioles vs Yankees Picks and Prediction – 6/21/2025

AL East Division rivals will square off on Saturday afternoon, when the Baltimore Orioles and the New York Yankees continue their series from the Bronx. Be ready for the baseball season with all of our MLB predictions. The Orioles (33-42) have won seven of their last 11 games and are trying to climb out of the division cellar. Last night, leadoff hitter Jackson Holliday went 3-for-5 with a run scored Baltimore to a 5-3 road victory.

Thirty-one year old righty Zach Eflin (6-3 4.81 ERA) will take the mound for the Orioles in this matchup. Last time out, Eflin (5.0 IP) was tagged for 12 hits and seven runs during a 7-1 road loss against Tampa Bay. 

The New York Yankees have dropped seven of their previous 11 games and are clinging to a two-game lead over Tampa Bay for first place. During Friday’s home loss, New York batters went 3-for-13 with runners in scoring position and left ten men on base. OF Aaron Judge collected three hits and crushed his 27th home run of the year for the Yankees (43-32), who fell to 22-16 at home. 

New York manager Aaron Boone will turn to right-hander Clarke Schmidt (3-3 3.16 ERA) on Saturday. Through 62 plus innings, Schmidt has allowed six home runs and fanned 60 batters while posting a solid 1.15 WHIP.

Baltimore 1B Ryan Mountcastle suffered a Grade 2 right hamstring strain and will be sidelined until August. Through 75 games, Baltimore ranks 18th in OPS and 23rd in runs scored. For the season, New York ranks 2nd in OPS and 3rd in runs scored. Take the Orioles to win on the road. Final Score Prediction, Baltimore Orioles win 6-4.