Orioles vs Twins Picks and Prediction – 5/6/2025

By: David Anicetti |

Last Updated: 05/05/2025 at 9:43 PM ET

Baltimore Orioles at Minnesota Twins 05/06/25 - MLB Picks & Predictions
Game Start: 5/6/2025, 11:40 PM UTC
Latest Odds: MIN -160 ; O/U 8.5

Orioles vs Twins Prediction

The Baltimore Orioles open a three-game series on the road Tuesday versus the Minnesota Twins. Baltimore is 13-20 following its 11-6 loss to the Kansas City Royals on Sunday. Baltimore lost two out of three over the weekend to Kansas City, and the Orioles have dropped six of the last 9. Baltimore is last in the American League East, 5 ½ games behind the first-place New York Yankees. Keep up to date with all the MLB action with our MLB picks.

Gunnar Anderson is batting .260 to lead Baltimore, and Ryan O’Hearn is the leader in home runs with seven. Cedric Mullins has 21 RBI, 28 hits, and an on-base percentage of .379 to lead Baltimore in the three categories. Baltimore is batting .227 with a .390 slugging percentage. On Tuesday, Baltimore will send Cade Povich to the mound. The left-hander is 1-2 with a 5.16 ERA, 25 Ks, and 12 BBs.

The Minnesota Twins improved to 15-20 following Sunday’s 5-4 victory over the Boston Red Sox. Harrison Bader’s double in the 8th inning drove in the go-ahead run for the Twins as Minnesota rallied to win for the second straight game at Fenway. Minnesota is 4th in the American League Central, seven games behind the first-place Detroit Tigers.

Byron Buxton is batting .260 with seven home runs and 33 hits to lead Minnesota in the three categories. Ty France is the leader in RBI with 19 and on-base percentage at .326. Minnesota is batting .236 with a .367 slugging percentage. On Tuesday, Minnesota will send Pablo Lopez to the mound. The right-hander is 2-2 with a 2.25 ERA, 26 Ks, and 4 BBs.

Orioles vs Twins Pick Analysis

While the UNDER is a solid choice, the play here is the Minnesota Twins. Minnesota has won seven of the last eight at home, while Baltimore has lost nine of its last 13 overall. Baltimore starter Cade Povich has given up 11 runs across the last 14.2 innings. Minnesota starter Pablo Lopez has had five consecutive solid outings, allowing seven runs across 28 innings. Final Score Prediction: Minnesota Twins win 5-2.

Our Free MLB Pick for Minnesota Twins vs Baltimore Orioles

Minnesota Twins -160