Orioles vs Brewers Picks and Prediction – 5/21/2025

In Wednesday afternoon MLB interleague action, the Baltimore Orioles will battle the Milwaukee Brewers from American Family Field. Be ready for the baseball season with all of our MLB predictions. The Orioles (15-31) are looking to snap a seven-game losing streak and have been the most disappointing team in the majors. Last night, Baltimore struck out 13 times and committed a pair of errors during a 5-2 road loss against Milwaukee. 

Thirty-five year old righty Tomoyuki Sugano (4-3 3.08 ERA) has been the lone bright spot in the Baltimore rotation. In his last start, Sugano lasted six plus innings and gave up four runs during a 4-0 home loss versus Minnesota. 

The Milwaukee Brewers have won the first two games of this series and are still 4.5 games out of first place in the NL Central Division. During Tuesday’s home victory, Milwaukee 1B Rhys Hoskins, 2B Brice Turang and OF Sal Frelick all homered. SP Logan Henderson (3-0) fanned seven batters across five shutout frames to earn the win for the Brewers (24-25), who improved to 15-9 at home. 

Rookie right-hander Chad Patrick (2-4 3.35 ERA) will make his tenth career major league start for the Brewers. Last time out, Patrick (6 IP) allowed eight hits and three runs during a 3-0 home loss versus Minnesota. 

Baltimore OF Tyler O’Neill has been placed on the 10-day injured list with a left shoulder impingement. Through 47 games, Baltimore ranks 22nd in OPS and 25th in runs scored. For the season, Milwaukee ranks 27th in OPS and 14th in runs scored. Take the Orioles to win on the road. Final Score Prediction, Baltimore Orioles win 6-2.