Orioles vs Tigers Picks and Prediction – 4/25/2025

Comerica Park will play host to a Friday night MLB clash between the Baltimore Orioles and the Detroit Tigers. Be ready for the baseball season with all of our MLB predictions. The Orioles (10-14) rank last in the majors with a 5.45 ERA and are stuck in the AL East Division basement. Last night, SP Cade Povich (1-2) allowed one run in six plus innings to lead Baltimore to a 2-1 road victory against Washington. 

Rookie right-hander Brandon Wright (0-0 6.75 ERA) will make his second career major league start for the Orioles. In his debut, Wright (4 IP) gave up seven hits and three runs during a 9-5 home victory versus Baltimore. 

The Detroit Tigers have won ten of their first 13 home games and hold a half-game lead over Cleveland for the top spot in the AL Central Division. On Wednesday, Detroit SP Reese Olson (3-1) fired seven plus shutout frames and fanned seven batters during a 6-0 home victory versus San Diego. DH Justyn-Henry Malloy homered and scored twice out of the leadoff spot for the Tigers, who improved to 15-10 overall.

The Tigers will turn to 2018 number one overall draft pick Casey Mize (3-1 2.22 ERA) in the series opener. Last time out, Mize (7 IP) allowed four hits and one run during a 3-1 home victory versus Kansas City. 

Baltimore SP Grayson Rodriguez has been diagnosed with a mild right lat strain and hopes to return later next month. Through 24 games, Baltimore ranks 18th in OPS and 19th in runs scored. For the regular season, Detroit ranks 14th in OPS and 10th in runs scored. Take the over. Final Score Prediction, Detroit Tigers win 6-5.