Orioles vs Guardians Picks and Prediction – 7/23/2025

The Orioles and Guardians wrap up a series on Tuesday at Progressive Field with the first pitch set for 4:40 PM ET. Baltimore is 44-55 overall and dropped the opener 10-5, while Cleveland sits at 49-50 after that win. The pitching matchup features veteran Charlie Morton (5-8, 5.58 ERA) for the Orioles against Slade Cecconi (5-4, 3.84 ERA) for the Guardians. Elevate your MLB game with our top-notch MLB picks.

Baltimore is in a rough patch, losing four of its last five, including Sunday’s loss to Cleveland, where the pitching collapsed for 10 runs. The lone bright spot recently was a 5-3 win over Tampa Bay. But offensive consistency has been a major issue. The Orioles average .239 at the plate and have produced 407 runs and 115 homers this year. Cedric Mullins leads the team with 13 home runs and 42 RBIs despite hitting just .216. Gunnar Henderson remains the best contact bat, slashing .279/.344/.459.

The pitching side has been a disaster with a team ERA of 5.00 and a WHIP of 1.43. Morton has struggled badly, allowing 97 hits and 13 homers in just under 89 innings. Opponents are hitting .268 against this staff, and the bullpen hasn’t helped. On the injury front, Baltimore remains shorthanded with Zach Eflin, Chadwick Tromp, and Keegan Akin all sidelined.

Cleveland has won five of its last six and looked sharp in the 10-5 win Sunday, led by a big day from José Ramírez. The offense has been picking it up recently despite a .225 average for the season. Ramírez has been the engine all year, batting .294 with 20 home runs and 55 RBIs, clearly the difference-maker in this lineup. The team’s OBP sits at .297 with 105 total home runs.

On the mound, the Guardians are far more stable. Cecconi has been solid, putting up a 3.84 ERA and 1.23 WHIP over 63.1 innings with 58 strikeouts and just 18 walks. The overall staff ERA of 3.95 and WHIP of 1.33 give Cleveland the edge, especially with opponents hitting only .245 against them. Cleveland’s bullpen has been steadier, and the Guardians have allowed fewer runs and walks than Baltimore across the board.

Cleveland has the better starter, a more stable bullpen, and the hotter bat in José Ramírez. Cecconi’s control and Baltimore’s 5.00 team ERA are too much to ignore. With Baltimore allowing way more runs and struggling at the plate lately, Cleveland should handle business again at home. Final Score Prediction: Cleveland Guardians win 6-4.