Orioles vs Red Sox Picks and Prediction – 5/22/2025

By: Cameron Ross |

Last Updated: 05/21/2025 at 9:27 PM ET

Baltimore Orioles at Boston Red Sox 05/22/25 - MLB Picks & Predictions
Game Start: 5/22/2025, 10:45 PM UTC
Latest Odds: BOS -112 ; O/U 8.5

Orioles vs Red Sox Prediction

The Baltimore Orioles stay on the road Thursday with a game in Boston against the Boston Red Sox. Baltimore is struggling immensely this season with just 15 wins through 47 games played riding a long losing streak coming into this matchup here offensively Baltimore has a .230 team batting average having scored 175 runs on 357 total hits this season. The Baltimore pitching has been horrendous as well with the 5.53 team ERA. Today in the news with our MLB Picks.

Ryan O’Hearn leads the Baltimore offense this season with a .289 batting average. Gunner Henderson has a .253 batting average to go along with a leading 41 hits this season. Emmanuel Rivera has a .282 batting average this season for Baltimore but has played in just fourteen games. Cedric Mullins leads the team with 10 home runs and thirty RBIs this season.

The Boston Red Sox will be back at home Thursday night with 25 wins and 25 losses on the year having won three of the last four including two in a row against the New York Mets. Offensively Boston has been solid enough with a .253 batting average as the Red Sox have scored 239 runs on 438 hits this season. The Boston pitching has held its own with a 4.01 ERA.

Alex Bregman leads the Boston offense this season with a .304 batting average and eleven home runs on the year. Wilyer Abreu has a .264 batting average and has also hit 11 bombs this season. Jaren Duran has a .264 batting average and Carlos Navarez has a .280 batting average Rafael Devers has a .286 batting average and leads Boston with 39 RBIs through 50 games played. Rob Refsnyder has a.295 batting average for Boston this season but has played just 16 times.

Orioles vs Red Sox Pick Analysis

Both teams send terrible arms to the plate but the Red Sox will have the edge. Boston has the superior offense that will get into the Baltimore bullpen early. The Red Sox also have the better bullpen to carry them if the starter struggles. Take Boston Thursday to do the job leading to the win. Final Score Prediction, Boston Red Sox win 7-2.

Our Free MLB Pick for Boston Red Sox vs Baltimore Orioles

Boston Red Sox -112