Diamondbacks vs Dodgers Picks and Prediction – 5/22/2025

This Wednesday, Corbin Burnes and the Arizona Diamondbacks face off against Dustin May and the Los Angeles Dodgers at Dodger Stadium in the second game of a pivotal National League West series. Get our free MLB Picks all season long! The Diamondbacks, now 26-22, are coming off a strong 9-5 win on Monday, powered by timely hitting and a relentless offensive approach.

Burnes has anchored Arizona’s rotation since arriving, using his elite cutter and command to carve up opposing lineups. He’ll face a Dodgers team that can do damage quickly, so maintaining efficiency and limiting walks will be critical. Arizona’s offense has been clicking, making this a tough challenge for Los Angeles

The Dodgers, sitting at 29-19, look to bounce back after surrendering nine runs in the opener. May returns to the mound needing a quality start to slow down the Diamondbacks’ momentum. When locked in, May’s combination of velocity and movement makes him nearly unhittable, but command will be key.

Los Angeles will need to get to Burnes early and avoid falling behind. Arizona, meanwhile, will aim to work counts, wear down May, and let Burnes do the rest. Run prevention and execution with runners in scoring position will likely determine who takes control of the series.

Burnes gives Arizona a slight edge with his consistency and ability to neutralize big bats. If May can’t match him inning for inning, the Diamondbacks should ride their momentum to another win. Take the Diamondbacks to upset the Dodgers for the second time in this season series. Final Score Prediction, Arizona Diamondbacks win 5-3.