Diamondbacks vs White Sox Picks and Prediction – 6/23/2025

In Monday night MLB action, the Arizona Diamondbacks will travel to Rate Field to battle the Chicago White Sox. Be ready for the baseball season with all of our MLB predictions. The Diamondbacks (39-38) are a game below .500 on the road and are sitting in fourth place in the NL West Division standings. On Sunday, Arizona SP Brandon Pfaadt (8-5) gave up four runs in five innings during a 4-2 road loss against lowly Colorado. 

Thirty-two year old southpaw Eduardo Rodriguez (2-4 5.93 ERA) will head to the hill for the Diamondbacks in this contest. Through 60 plus innings, Rodriguez has fanned 64 batters and owns an alarming 1.62 WHIP.

The Chicago White Sox have dropped eight of their previous ten games and own the worst overall record in the American League. On Sunday, 1B Miguel Vargas delivered a go-ahead two-run double in the eighth inning to lift Chicago to a 4-2 road victory against Toronto. SP Adrian Houser allowed a pair of runs across six plus frames and did not factor in the decision for the White Sox (25-53).

Rookie right-hander Shane Smith (3-4 2.85 ERA) will make his 15th career major league start for the White Sox. Last time out, Smith (4.1 IP) gave up six hits and six runs (5 ER) during a 12-2 home loss versus St. Louis.

Arizona OF Corbin Carroll (hand) was not in Sunday’s lineup and is listed as day-to-day. Through 77 games, Arizona ranks 3rd in OPS and 3rd in runs scored. For the season, Chicago ranks 4th in OPS and 2nd in runs scored. Take the over. Final Score Prediction, Arizona Diamondbacks win 6-5.