Diamondbacks vs Cubs Picks and Prediction – 4/20/2025

The Chicago Cubs remain at home on Sunday with the Arizona Diamondbacks in town. The Cubs are 14-9 on the season and lead the NL Central. Chicago has won six of their last ten games. The Cubs are riding a two game win streak and carry a 6-4 home field record. Chicago leads the MLB with an average of 6.2 runs scored per game. Stay up to date with our expert's MLB Picks 

Jameson Taillon will make his 5th start on the hill for the Chicago Cubs. Taillon is 1-1 on the season with 21.2 innings pitched. Taillon has 18 strikeouts and carries a 5.40 ERA. Taillon pitched 5.1 innings in his last outing allowing 2 runs and 3 hits. The Chicago Cubs are allowing an average of 4.45 runs against per game. 

The Arizona Diamondbacks are 12-9 on the season. Arizona is 7-3 over their last ten games. The Diamondbacks are riding a two game losing streak and carry a 6-5 road record. Arizona is averaging 5.8 runs scored per game which is 2nd best in the MLB. 

Merrill Kelly will make his 5th start on the mound for the Arizona Diamondbacks. Kelly is 3-1 on the season with 21 innings pitched. Diamondbacks has 16 strikeouts and carries a 5.57 ERA. Arizona is allowing an average of 4.55 runs against per game. 

The Chicago Cubs are seeking a third straight win. While the Arizona Diamondbacks are trying to avoid a third straight loss. The Cubs have outscored the Diamondbacks 19-13 over their last two games. Watch for the Cubs to complete the weekend sweep at Wrigley Field. Final Score Prediction, Chicago Cubs win 5-3.