Diamondbacks vs Cubs Picks and Prediction – 4/19/2025

Historic Wrigley Field will play host to a Saturday afternoon MLB matchup between the Arizona Diamondbacks and the Chicago Cubs. Be ready for the baseball season with all of our MLB predictions. The Diamondbacks (12-8) have won seven of their last ten games and are sitting in fourth place in the ultra-competitive NL West Division standings. On Friday, Arizona’s ten-run eighth inning was not enough during a wild 13-11 road loss against Chicago. Eugenio Suarez hit a grand slam and Lourdes Gurriel Jr. added a three-run shot. 

Twenty-nine year old righty Zac Gallen (1-2 4.64 ERA) will take the mound for the Diamondbacks in this matchup. In his last start, Gallen (6 IP) allowed two runs and struck out five batters during a 5-2 home victory versus Milwaukee. 

The Chicago Cubs are a game above .500 at home and hold a 1.5 game lead over Milwaukee for the top spot in the NL Central Division. In yesterday’s series opener, C Carson Kelly homered twice and drove in five runs to power the Chicago offense. Ian Happ crushed a grand slam and Kyle Tucker added a game-winning two-run blast for the Cubs. 

Chicago manager Craig Counsell will give the nod to twenty-five year old righty Ben Brown (2-1 5.09 ERA) on Saturday. Last time out, Brown scattered five hits across six shutout frames during a 16-0 road triumph against Los Angeles. 

Arizona 2B Ketel Marte (hamstring) took live batting practice on Tuesday and hopes to return to the lineup early next month. Through 20 games, Arizona ranks 2nd in OPS and 3rd in runs scored. For the regular season, Chicago ranks 3rd in OPS and 1st in runs scored. Take the Diamondbacks to win on the road. Final Score Prediction, Arizona Diamondbacks win 4-3.