Wake Forest vs Louisville Picks and Prediction – 1/29/2025

By: David Anicetti |

Last Updated: 01/27/2025 at 7:23 PM ET

Wake Forest at Louisville 01/28/25 - NCAAB Picks & Predictions
Game Start: 1/29/2025, 12:00 AM UTC
Latest Odds: LOU -7.5 ; O/U 142

Wake Forest vs Louisville Prediction

The Wake Forest Demon Deacons visit KFC Yum! Center in Louisville, Kentucky on Tuesday to play the No. 25-ranked Louisville Cardinals in an Atlantic Coast Conference clash. Wake Forest is 15-5 overall and 7-2 in ACC play. Wake Forest lost to the No. 2-ranked Duke Blue Devils 63-56 on Saturday. The loss snapped a six-game winning streak by the Demon Deacons. Keep up to date with all the NBA action with our NBA predictions.

Hunter Sallis leads Wake Forest in scoring, averaging 18.9 points per game. Cameron Hildreth is second in scoring and the leader in assists, averaging 13.7 points and 3.2 assists per game. Tre’Von Spillers leads Wake Forest in rebounding, averaging 8.5 rebounds per game. Wake Forest has three players who average double figures in scoring. The Demon Deacons score an average of 70.0 points per game.

The Louisville Cardinals will look for a 10th consecutive win on Tuesday when hosting the Wake Forest Demon Deacons. Louisville is 15-5 overall and 8-1 in ACC play. The Cardinals beat SMU 98-73 last Tuesday. Reyne Smith was the leading scorer for Louisville with 30, which matches his career high. Smith set a school record when hitting 10 3-pointers.

Chucky Hepburn leads Louisville in scoring and assists, averaging 15.1 points and 6.3 assists per game. J’Vonne Hadley leads the Cardinals in rebounding, averaging 7.6 per game. Reyne Smith is second in scoring, averaging 14.5 points per game, and one of five players who average double figures in scoring. Louisville scores an average of 79.4 points per game. 

Wake Forest vs Louisville Pick Analysis

In what should be a very closely contested game from start to finish, the Louisville Cardinals will win and cover at home on Tuesday when hosting the Wake Forest Demon Deacons. Louisville has covered the number in six of its last seven. Louisville's defense holds opponents to 69.8 points per game, while the Cardinals average 79.4 points per game. However, the big difference in this matchup will be Louisville playing at home. Final Score Prediction, Louisville Cardinals win but fail to cover ATS 75-69.

Our Free NCAA Basketball Pick for Louisville vs Wake Forest

Wake Forest Demon Deacons +7.5