Defenders vs Panthers Picks and Prediction – 5/4/2025

By: David Anicetti |

Last Updated: 04/28/2025 at 3:34 PM ET

D.C. Defenders at Michigan Panthers 05/04/25 - UFL Picks & Predictions
Game Start: 5/4/2025, 4:00 PM UTC
Latest Odds: MICH -2.5 ; O/U 41.5

Defenders vs Panthers Prediction

The DC Defenders visit Ford Field in Motown on Sunday to play the Michigan Panthers in a UFL Week 6 showdown. DC is 4-1 and first in the XFL Conference. The Defenders defeated the Arlington Renegades 37-33 last Sunday. DC quarterback Jordan Ta’amu threw for 308 yards with three touchdowns and one interception. Cornell Powell caught four passes for 89 yards and one touchdown. Make sure you stay up to date with UFL action with our expert UFL picks.

DC quarterback Jordan Ta’amu is having an MVP season. Ta’amu has thrown for 1,213 yards with nine touchdowns and four interceptions. Abram Smith is the leading rusher for DC with 193 yards. The leading receiver is Chris Rowland with 251 yards and two touchdown receptions. Anthony Hines is the leading tackler with 19 solo and 10 assisted for 29, and Momo Sanogo is second with nine solo and 14 assisted for 23.

The Michigan Panthers are 3-2 and tied with the Birmingham Stallions at the top of the USFL Conference, one game ahead of the Houston Roughnecks. Michigan lost to the St Louis Battlehawks 32-27 last Saturday. Michigan quarterback Bryce Perkins passed for 235 yards with two touchdowns, and backup Danny Etling had 59 yards passing and one interception. 

Michigan quarterback Bryce Perkins has thrown for 923 yards with six touchdowns and two interceptions. Nate McCrary is the leading rusher with 184 yards and one touchdown. Siaosi Mariner is the leading receiver with 282 yards. Frank Ginda is the leading tackler with 24 solo and 17 assisted for 41. Kedrick Whitehead is second with 17 solo and 18 assisted, for 25. 

Defenders vs Panthers Pick Analysis

The DC Defenders have scored an average of 23.5 points per game and are first in total offense at 327.8 yards per game. DC will face a Michigan defense that is allowing an average of 19.4 points and 244.2 yards per game. DC quarterback Jordan Ta’amu is leading the UFL in passing with 1,213 yards, 9 touchdowns, and four interceptions. Ta’amu’s passing will be too much for the Michigan defense to contain. Final Score Prediction: DC Defenders win and cover ATS 27-13.

Our Free UFL Pick for Michigan Panthers vs D.C. Defenders

DC Defenders +2.5