Tennessee Titans at Buffalo Bills 9/19/22 - NFL Picks & Predictions

Last Updated: 09/12/2022 at 10:53 PM ET

Tennessee Titans at Buffalo Bills 9/19/22 - NFL Picks & Predictions

Highmark Stadium will play host to a Monday night NFL clash between the Tennessee Titans and the Buffalo Bills. The Titans have won at least nine games in each of the previous six seasons and are the two-time defending AFC South Division champs. On Sunday, Tennessee K Randy Bullock missed a 47-yard field goal as time expired during a 21-20 home loss versus the New York Giants. Check out all of our best NFL picks.

Tennessee WR Dontrell Hilliard caught touchdown passes of seven and 23 yards from Ryan Tannehill, who finished with 266 yards passing. Derrick Henry added 82 rushing yards on 21 carries in a losing effort for the Titans.

The Buffalo Bills fell short against Kansas City in a classic AFC Divisional playoff loss and enter the 2022 campaign as the favorites to win the Super Bowl. In their season opener, Buffalo shutout defending Super Bowl Champion Los Angeles in the second half of a 31-10 road triumph. The Bills (1-0) outgained the Rams by a 413-243 margin and overcame four turnovers.

QB Josh Allen led Buffalo’s offense with 297 yards through the air (3 TD) and 56 rushing yards (1 TD). Stefon Diggs caught eight passes for 122 yards and found the end zone on a 53-yard strike to cap the scoring.

Buffalo CB Tre’Davious White (torn ACL) has been placed on the PUP list and is not eligible to return until week five. The Titans are coming off a disappointing loss and will be motivated to avoid an 0-2 start. Unfortunately, the Bills are too talented and will win at home in a game that stays under the total. Final Score Prediction, Buffalo Bills win 27-17.

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