Seattle Seahawks at San Francisco 49ers 9/18/22 - NFL Picks & Predictions

Last Updated: 09/17/2022 at 10:01 AM ET

The Seattle Seahawks head into San Francisco in Week 2 to take on the 49ers. The Seahawks went into Monday night's game as a six game underdog and beat Denver outright. Quarterback Geno Smith led the way with 2 passing touchdowns. Smith went 23/28 for 195 yards. Wide receiver Will Dissly and Colby Parkinson both had 43 yards and caught a touchdown. DK Metcalf had 7 catches for 36 yards.

The Seattle Seahawks beat Denver on Monday night despite not scoring a single point in the second half. The Seahawks allowed 330 passing yards which ranks 30th in the NFL. Seattle's defense had 2 sacks in the win. 

The San Francisco 49ers head back home after losing in Chicago 19-10 in their first game. Quarterback Trey Lance went 13/28 for 164 yards and an interception. Lance also rushed 13 times for 54 yards. The San Francisco 49ers rank 7th in the NFL after one game with 176 rushing yards. 

The 49ers only touchdown against the Bears came from Deebo Samuel. Samuel had 2 receptions but was targeted 8 times. Wide receiver Jauan Jennings led the 49ers with 4 receptions for 62 yards. The 49ers defense ranks 1st in the league allowing 220 yards against the Bears.

The Seattle Seahawks controlled the ball enough and had a good start in their first win. The Seahawks show value as underdogs against the 49ers. San Francisco defense may have been impressive in their loss but their offense could not find the endzone. Grab those free points in what will be a close game. Final Score Prediction, San Francisco 49ers win but the Seattle Seahawks cover ATS 17-14.

Download the Picks and Parlays Mobile App

Get A free VIP Pick Daily!