Seattle Seahawks at Arizona Cardinals 11/6/22 - NFL Picks & Predictions

The Arizona Cardinals host the NFC West Division leading Seattle Seahawks on Nov. 6. Seattle has won three of the last four games against Arizona, including a 19-9 victory at home on Oct. 16.

The Seahawks are 5-3 so far this season and 2-2 on the road. They are also 5-3 and 2-2 against the spread. The Cardinals are 3-5 overall and 1-3 at home. Against the spread, they are 4-4 and 2-2 at home.

Seattle outscored the New York Giants 17-3 in the fourth quarter Sunday to secure a 27-13 home win. The Seahawks defense limited the Giants to 225 yards of total offense, including just 78 rushing yards. Seattle’s offense accumulated just 277 yards, but it came through late to get the win.

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Geno Smith has found new life in Seattle with Russel Wilson gone to Denver. He has completed 72.7% of his passes, 181-for-249, for 1,924 yards and 13 touchdowns with just three interceptions. The Seahawks running attack has remained strong despite losing Rashaad Penny for the season in Week 5. Kenneth Walker III was held to 51 yards by the Giants but has racked up 461 yards and five touchdowns on 85 carries this season.

Arizona has dropped three of its last four games, including a 34-26 loss at Minnesota on Sunday. The Vikings led the entire game, but the Cardinals pulled to within two points, 28-26, with 12:32 to play. Minnesota would go up 12 less than four minutes later, however, to get the victory.

Kyler Murray completed 31-of-44 passes for 326 yards and three touchdowns, but he also through two interceptions. Both picks led to Vikings touchdowns. Murray was the leading rusher for Arizona, with 36 yards on six runs. Running back Eno Benjamin was held to just 22 yards with nine carries.