San Francisco 49ers at Philadelphia Eagles 9/19/21 - NFL Picks & Predictions

The San Francisco 49ers visit Lincoln Financial Field in Philadelphia, Pennsylvania on Sunday to play the Philadelphia Eagles. San Francisco opened its regular season with a 41-33 victory over the Detroit Lions. San Francisco quarterback Jimmy Garoppolo threw for 314 yards and one touchdown and rookie Trey Lance threw a touchdown pass in his debut for the 49ers. San Francisco built a 28-point lead but had to hold on in the end.

Jimmy Garoppolo has thrown for 314 yards and one touchdown. The leading rusher for San Francisco is Elijah Mitchell with 104 yards and one touchdown but starting running back Raheem Mostert was lost to a lower leg injury. Deebo Samuel is the leading receiver for San Francisco with 189 yards and one touchdown. Linebacker Fred Warner is the leader in tackles with 11.

Philadelphia opened its regular season with an impressive 32-6 victory over the Atlanta Falcons. Eagles quarterback Jalen Hurts passed for three touchdowns and first year head coach Nick Sirianni won in his debut. The Eagles gained 434 yards of total offense, while holding Atlanta to just 260 yards of total offense.

Jalen Hurts has passed for 264 yards with three touchdowns and was sacked once. Miles Sanders is the leading rusher for Philadelphia with 74 yards and an average of 4.9 yards per carry. The leading receiver is DeVonta Smith with 71 yards, one touchdown and an average of 11.8 yards per reception. Cornerback Avonte Maddox and linebacker Eric Wilson are the leading tacklers with nine apiece.