49ers vs Rams Picks and Prediction – 9/22/2024

SoFi Stadium will play host to a Sunday afternoon NFL battle between the San Francisco 49ers and the Los Angeles Rams. For other NFL news see our NFL Picks. The 49ers (1-1) are in 2nd place in the NFC West division and rank 11th in the league in team points per game at 24.5 points. Last week, San Francisco only put 7 points on the scoreboard in the first half and then only 10 points in the 2nd half resulting in a 23-17 away loss versus Minnesota. Sam Darnold finished 17-of-26 for 268 yards and two touchdowns, including an epic 97-yard strike to Justin Jefferson, to lead the Minnesota Vikings to victory over the San Francisco 49ers on Sunday. San Francisco QB Brock Purdy threw one interception and was sacked 6 times, and fumbled once. San Francisco Running Back Jordan Mason had 20 carries for 100 yards and one touchdown. Wide Receiver Deebo Samuel Sr finished the game with 110 yards receiving leading the 49ers.

The Los Angeles Rams (0-2) Quarterback Matthew Stafford was sacked five times and fumbled once as the Rams lost 41-10 against the Arizona Cardinals. To make matters worse, star receiver Cooper Kupp left in the second quarter with an ankle injury and didn’t return. The Rams have had a rough run of injuries through the first two weeks, putting three key players on injured reserve this week. Rams Safety John Johnson III (shoulder) left the game in the second half. 

The San Francisco 49ers will be looking to bounce back after the loss to Minnesota. The 49ers should be able to control the line of scrimmage, pass and run the ball against the Rams who are ranked last in the NFL in total yards given up after two games played. The Rams have given up 33.5 points per game so far. Final Score Prediction, San Francisco 49ers win and cover the spread 24-16.