San Francisco 49ers at Detroit Lions 9/12/21 - NFL Picks & Predictions

Game: Detroit Lions vs San Francisco 49ers
Date & Time: 9/12/2021, 5:00 PM UTC
Location: Ford Field
Address: Detroit, MI
Latest Odds: SF -7.5 ; O/U 46
TV Channel: FOX

San Francisco was able to finish the preseason on a high note. The 49ers were able to win over the Raiders by a score of 34-10. Now, the 49ers are looking to build upon that success and continue to carry it over to the regular season here.

The 49ers are going to be guided on the field by Jimmy Garoppolo. Now, the downside is Garoppolo is oft injured and has a reputation, but the quarterback depth after him is severely lacking with how the 49ers have done. Nick Bosa, if healthy, could be a defensive force to be reckoned with and could easily dominate the games.

A change of players and leaders of the Lions franchise will definitely not make much of a difference. The culture of losing has become embedded in the Lions and it seems that even with all the changes that have been made the players seem to fall into the same lull of not being able to get the win at the last minute.

Jared Goff is the leader for the Lions offense. That may not really sound that bad, but if you look at how Goff has done in the past in Los Angeles it seems to be that Goff has a bad habit of choking. That definitely could be an issue here for the Lions as well, but the Lions are used to losing.

The lack of leadership for the Lions on a consistent enough basis to become a threat is definitely going to make it harder to see the Lions win in this game. The Lions, though, are going to struggle defensively as well and that may make it harder to stop the 49ers offense. Look for San Francisco to dominate this game on both sides of the ball and easily lock down the win. Final Score Prediction, San Francisco 49ers win and cover 31-14.

The 49ers are 3-6 ATS in their last 9 games.

The 49ers are 1-4 in their last 5 games.

The total has gone over in 7 out of the last 10 Lions games.

The Lions are 1-6 in their last 7 games.

San Francisco was able to finish the preseason on a high note. The 49ers were able to win over the Raiders by a score of 34-10. Now, the 49ers are looking to build upon that success and continue to carry it over to the regular season here.

The 49ers are going to be guided on the field by Jimmy Garoppolo. Now, the downside is Garoppolo is oft injured and has a reputation, but the quarterback depth after him is severely lacking with how the 49ers have done. Nick Bosa, if healthy, could be a defensive force to be reckoned with and could easily dominate the games.

A change of players and leaders of the Lions franchise will definitely not make much of a difference. The culture of losing has become embedded in the Lions and it seems that even with all the changes that have been made the players seem to fall into the same lull of not being able to get the win at the last minute.

Jared Goff is the leader for the Lions offense. That may not really sound that bad, but if you look at how Goff has done in the past in Los Angeles it seems to be that Goff has a bad habit of choking. That definitely could be an issue here for the Lions as well, but the Lions are used to losing.

The lack of leadership for the Lions on a consistent enough basis to become a threat is definitely going to make it harder to see the Lions win in this game. The Lions, though, are going to struggle defensively as well and that may make it harder to stop the 49ers offense. Look for San Francisco to dominate this game on both sides of the ball and easily lock down the win. Final Score Prediction, San Francisco 49ers win and cover 31-14.

The 49ers are 3-6 ATS in their last 9 games.

The 49ers are 1-4 in their last 5 games.

The total has gone over in 7 out of the last 10 Lions games.

The Lions are 1-6 in their last 7 games.

San Francisco was able to finish the preseason on a high note. The 49ers were able to win over the Raiders by a score of 34-10. Now, the 49ers are looking to build upon that success and continue to carry it over to the regular season here.

The 49ers are going to be guided on the field by Jimmy Garoppolo. Now, the downside is Garoppolo is oft injured and has a reputation, but the quarterback depth after him is severely lacking with how the 49ers have done. Nick Bosa, if healthy, could be a defensive force to be reckoned with and could easily dominate the games.

A change of players and leaders of the Lions franchise will definitely not make much of a difference. The culture of losing has become embedded in the Lions and it seems that even with all the changes that have been made the players seem to fall into the same lull of not being able to get the win at the last minute.

Jared Goff is the leader for the Lions offense. That may not really sound that bad, but if you look at how Goff has done in the past in Los Angeles it seems to be that Goff has a bad habit of choking. That definitely could be an issue here for the Lions as well, but the Lions are used to losing.

Odds Table

Betting Trends

  • The 49ers are 3-6 ATS in their last 9 games.
  • The 49ers are 1-4 in their last 5 games.
  • The total has gone over in 7 out of the last 10 Lions games.
  • The Lions are 1-6 in their last 7 games.
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The lack of leadership for the Lions on a consistent enough basis to become a threat is definitely going to make it harder to see the Lions win in this game. The Lions, though, are going to struggle defensively as well and that may make it harder to stop the 49ers offense. Look for San Francisco to dominate this game on both sides of the ball and easily lock down the win. Final Score Prediction, San Francisco 49ers win and cover ATS 31-14.

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