San Francisco 49ers at Denver Broncos 9/25/22 - NFL Picks & Predictions

The San Francisco Giants visit Empower Field at Mile High to play the Denver Broncos on NFL Sunday Night Football. San Francisco improved to 1-1 following its 27-7 victory over the Seattle Seahawks on Sunday. San Francisco starting quarterback Trey Lance was carted off the field with a season-ending injured ankle but veteran Jimmy Garoppolo came on and led the 49ers to the victory.

San Francisco quarterback Jimmy Garoppolo has passed for 154 yards with one touchdown. The leading rusher is Jeff Wilson Jr. with 106 yards, while Deebo Samuel has rushed for 105 yards and one touchdown. Brandon Aiyuk is the leading receiver with 103 yards. On defense, Talanoa Hufanga is the leading tackler with 17. San Francisco has four quarterback sacks and three interceptions.

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Denver improved to 1-1 following its 16-9 victory over the Houston Texans on Sunday. Denver gained 350 yards of total offense and the Broncos’ defense held Houston to 234 yards of total offense in a field goal fest, as just one touchdown was scored between the two teams with six field goals. Russell Wilson passed for 219 yards with one touchdown and one interception as the catalyst of the Denver offense.

Denver quarterback Russell Wilson has passed for 559 yards with two touchdowns and one interception. The leading rusher is Javonte Williams with 118 yards, while Melvin Gordon III has rushed for 105 yards. The leading receiver is Courtland Sutton with 194 yards. On defense, linebacker Alex Singleton is the leading tackler with 14. Denver has five quarterback sacks and no interceptions.