San Francisco 49ers at Buffalo Bills Prop Bets – Sunday 12/1/2024

The San Francisco 49ers will be on the road Sunday night with a game in New York against the Buffalo Bills. Both teams come into Sunday looking for success as each have gone in different directions this season. Expect both teams to cash in multiple props as each pursues a victory on prime time. Stay up to date with our NFL Picks.

Christian McCaffery Over 52.5 Rushing Yards

Dawson Knox Over 24.5 Receiving Yards

Brock Purdy Over .5 Interceptions

Christian McCaffery

Despite the missed time this season Christian McCaffrey is still one of the best running backs in football. McCaffrey must get it going in a big way for San Francisco to turn their season around. Look for Christian to do the job Sunday night as he goes over 52.5 rushing yards against Buffalo.

Pick:Christian McCaffery Over 52.5 Rushing Yards

Dawson Knox 

Dawson Knox is a constant target for the Buffalo Bills and that will continue Sunday. Look for Knox to find holes in the defense throughout the game leading to success. Take Dawson to go over 24.5 receiving yards against San Francisco.

Pick:Dawson Knox Over 24.5 Receiving Yards

Brock Purdy 

Brock Purdy has been up and down thus far this season and will struggle again on Sunday. Look for Purdy to find some success but the Buffalo defense will rough him up here and there. Take Brock to throw at least one interception Sunday night on prime time.

Pick:Brock Purdy Over .5 Interceptions