49ers vs Cardinals Picks and Prediction – 1/4/2025

State Farm Stadium will play host to a Sunday afternoon NFL battle between the San Francisco 49ers and the Arizona Cardinals. For other NFL news see our NFL Picks. The 49ers (6-10) are in 4th place in the NFC West division and rank 15th in the league in team points per game at 15.0 points. Last week, Miami Dolphins cornerback Kader Kohou intercepted 49ers quarterback Brock Purdy late in Miami's 29-17 win over San Francisco in week 16. The 49ers were eliminated from the postseason before the game because of wins by the Los Angeles Rams and Washington Commanders earlier Sunday. The loss ensured that last year’s NFC champions will have a losing season for the first time since 2020. The 49ers were penalized 11 times total for 90 yards. San Francisco has only won one game in their last six games played.

The Arizona Cardinals (7-9) for the 2nd time in three seasons, will wrap up the regular season at home vs. the defending NFC champion 49ers. RB James Conner has 6 TDs in 5 games vs. the 49ers since he joined the Cardinals in 2021. The Cardinals were eliminated from playoff contention in week 16. Last week, Ahkello Witherspoon makes a last-minute interception to preserve the Rams' 13-9 win over Arizona in week 17. James Conner suited up despite a knee injury, but had just four ineffective carries before getting shut down. Arizona has only won one game in their last six games played. 

The San Francisco 49ers are 2-5 away from home this season. The 49ers will be glad this dreadful season will be over after this week. San Francisco is down to their 3rd string running back and both tackles on the offensive line are hurting. The 49ers defense is also banged-up especially their secondary. The Arizona Cardinals are 5-3 at home and only have injuries to the running backs. Kyler Murray had a good game against San Francisco last time scoring on a 50 yard run and throwing a touchdown. Arizona will do enough at State Farm Stadium and get the win. Final Score Prediction, Arizona wins 24-21.