Patriots vs 49ers Picks and Prediction – 9/29/2024

The New England Patriots remain on the road this week with the game out West in Santa Clara against the San Francisco 49ers. New England has struggled immensely this season with just one win in three games played riding a three-game skid following a blowout 21 point loss on Thursday Night Football to the New York Jets. Offensively the Patriots rank 30th in the NFL averaging just 13 points per game. Defensively New England is giving up just under 330 total yards per game and ranks 10th in the league allowing 19 points per game. For more NFL news see our NFL Picks.

Jacoby Brissett is leading the New England offense this season with 368 yards and one score on 42 completions to go along with 38 yards on 9 carries. Rhamondre Stevenson leads the team with 224 yards and two touchdowns on 52 carries through three games. Antonio Gibson is second on the roster with 143 yards on 23 berries. Hunter Henry is the only real threat from the New England receivers leading the team with 136 yards on 12 catches this year.

The San Francisco 49ers come into this week with just one win in three games played on a 2-game losing streak following a three-point loss on the road against Los Angeles. Offensively San Francisco has been phenomenal this season ranking #9 in scoring offense posting 24.5 yards per game. The 49ers have the number 3 ranked passing attack averaging 259 yards, while boasting a top 15 rushing attack compiling 141 yards per game this season. Defensively San Francisco has been just below their expectations allowing 21 points per game ranking them 17th in the NFL.

Brock Purdy leads the San Francisco offense this season with 842 yards and four scores on 69 completions this season. Jordan Mason is the top ball carrier thus far with 324 yards and two scores on 67 carries. Jauan Jennings leads San Francisco with 276 yards and three scores on 18 receptions. Deebo Samuel Jr has 164 yards on 13 catches and Brandon Aiyuk  has added 119 yards on 11 catches.

Both teams have had a ton of struggles to start the year as each have won just 1 of the first 3 games. Both teams will come into this matchup focused and locked in with an emphasis on turning things around. The Niners should do enough on their home field to get the win but the issues and injuries will prevent a cover. Take New England to do enough this week to cover the number as they pursue the out right underdog win. Final Score Prediction, San Francisco 49ers win but the New England Patriots cover 27-21.