Minnesota Vikings at San Francisco 49ers 11/28/21 - NFL Picks & Predictions

Last Updated: 11/22/2021 at 1:15 PM ET

The Minnesota Vikings visit Levi's Stadium in Santa Clara, California on Sunday to play the San Francisco 49ers. Minnesota is 5-5 and second in the NFC North following its 34-31 loss to the Green Bay Packers on Sunday. Kirk Cousins passed for 341 yards with three touchdowns and Justin Jefferson caught eight passes for 169 yards and two touchdowns in the loss.

Kirk Cousins has passed for 2,775 yards with 21 touchdowns and just two interceptions. The leading rusher for Minnesota is Dalvin Cook with 734 yards and four touchdowns, while the leading receiver is Justin Jefferson with 944 yards and six touchdown receptions. On defense, linebacker Eric Kendricks is the leading tackler with 102 and defensive end Danielle Hunter is the leader in quarterback sacks with 6.0.

San Francisco improved to 5-5 following a 30-10 victory over the Jacksonville Jaguars on Sunday. San Francisco gained 333 yards of total offense and held Jacksonville to 200 yards of total offense. Quarterback Jimmy Garoppolo passed for 176 yards with two touchdowns. San Francisco forced two Jacksonville turnovers in the victory.

San Francisco quarterback Jimmy Garoppolo has passed for 2,112 yards with 12 touchdowns and five interceptions, The leading rusher is Elijah Mitchell with 560 yards and three touchdowns, while the leading receiver is Deebo Samuel with 994 yards and five touchdown receptions. On defense, linebacker Fred Warner is the leading tackler with 89 and defensive end Nick Bosa is the leader in quarterback sacks with 10.0.

San Francisco is coming off a solid victory over Jacksonville, while Minnesota was defeated by Green Bay, but the play here is UNDER. The UNDER has cashed in each of the last four overall between these two NFC Rivals and in each of the last four played between the two in San Francisco. San Francisco allows an average of only 22.2 points per game which is 11th best in the NFL and Minnesota is only 13th best in the NFL in scoring with an average of 25.5 points per game. Final Score Prediction, San Francisco 49ers win but our best play is UNDER 24-21.

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