Los Angeles Rams at San Francisco 49ers 10/3/22 - NFL Picks & Predictions

Beautiful Levi’s Stadium will play host to a Monday night NFL clash between the Los Angeles Rams and the San Francisco 49ers. The Super Bowl Champion Rams (2-1) lost their season opener versus Buffalo and have rebounded for consecutive victories. On Sunday, Los Angeles raced out to a 10-point lead after one quarter and cruised to a 20-12 road victory against Arizona.

All-Pro WR Cooper Kupp scored the first touchdown of the game for Los Angeles on a 20-yard jet sweep. RB Cam Akers contributed 61 rushing yards on 61 carries and found paydirt on a 14-yard run. Rams need to get some help from the supporting cast for Kupp and Stafford this week.

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The San Francisco 49ers lost starting QB Trey Lance for the season in week two and have turned to veteran QB Jimmy Garoppolo. On Sunday night, San Francisco committed three turnovers during an 11-10 road loss against Denver. The 49ers’ potent rushing attack was limited to 88 yards and the Broncos possessed the ball for 34 plus minutes.

Garoppolo put San Francisco on the scoreboard first on a three-yard touchdown pass to Brandon Aiyuk. Deebo Samuel added five catches for 73 yards in a losing effort for the 49ers (1-2).