Los Angeles Rams at Arizona Cardinals 9/25/22 - NFL Picks & Predictions

Game: Arizona Cardinals vs Los Angeles Rams
Date & Time: 9/25/2022, 8:25 PM UTC
Location: State Farm Stadium
Address: Glendale, AZ
Latest Odds: LAR -4.5 ; O/U 51
TV Channel: FOX

On Sunday, the Los Angeles Rams visit State Farm Stadium in Glendale, Arizona for an NFC West showdown against the Arizona Cardinals. Los Angeles improved to 1-1 following its 31-27 victory over the Atlanta Falcons on Sunday. Los Angeles gained 337 yards of total offense but committed three turnovers. The Rams allowed only 261 yards of total offense and forced three Falcons’ turnovers. 

Los Angeles quarterback Matthew Stafford has passed for 512 yards with four touchdowns and five interceptions. The leading rusher is Darrell Henderson Jr with 94 yards and one touchdown, while the leading receiver is Cooper Kupp with 236 yards and three touchdowns receptions. On defense, linebacker Ernest Jones is the leading tackler with 19. Los Angeles has five quarterback sacks and four interceptions.

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Arizona improved to 1-1 following its 29-23 overtime victory against the Las Vegas Raiders. Arizona trailed 20-7 starting the fourth quarter but scored 16 unanswered points in the final quarter to send the game to overtime. Arizona won on a fumble return of 59 yards for a touchdown in the extra period. Arizona gained 413 yards of total offense and allowed Las Vegas 324 yards of total offense.

Arizona quarterback Kyler Murray has passed for 470 yards with three touchdowns and one interception. The leading rusher is Darrell Williams with 59 yards and one touchdown, while the leading receiver is Greg Dortch with 118 yards and one touchdown reception. On defense, safeties Budda Baker and Jalen Thompson are the leading tacklers with 19 each. Arizona has one quarterback sack and no interceptions.

Odds Table

Betting Trends

  • Los Angeles is 0-4 ATS in its last 4
  • The OVER has cashed in 6 of the Rams last 7 in September
  • Arizona is 2-6 ATS in its last 8
  • The OVER has cashed in 4 of the Cardinals last 5 at home 

Both defenses are off to poor starts as Arizona is next to last in points allowed at 33.5 points per game and Los Angeles is 29th allowing an average of 29.0 points per game. Therefore the play here is OVER. The OVER has cashed in six of the Rams last seven played in September. The OVER has cashed in four of Arizona’s last five at home. Final Score Prediction, Los Angeles Rams win but our best play is OVER 30-27.


Terry Edelmann
WIN/LOSS 64/51
PROFIT $1464.00
Ricky Tran
WIN/LOSS 39/20
PROFIT $1361.00
Ross Benjamin
WIN/LOSS 36/22
PROFIT $1176.00
The Insiders
The Insiders Room
WIN/LOSS 45/30
PROFIT $1101.00
Tony Karpinski
WIN/LOSS 37/25
PROFIT $986.00

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