Chargers vs Cardinals Picks and Prediction – 10/22/2024

In Monday night NFL action, the Los Angeles Chargers will travel to State Farm Stadium to face the Arizona Cardinals. Get ready for all the football action with our NFL Picks. The Chargers (3-2) have taken on a new identity under first year head coach Jim Harbaugh and lead the league in scoring defense (13.2 ppg). On Sunday, Los Angeles held Denver scoreless for the first three quarters and forced a pair of turnovers during a 23-16 road victory. 

QB Justin Herbert threw for 237 yards and found Kimani Vidal on a 38-yard touchdown pass to give Los Angeles a 10-0 lead. J.K. Dobbins contributed 96 rushing yards and a score for the Chargers, who outgained the Broncos by a 350-316 margin.

The Arizona Cardinals have dropped two of their first three home games and are one game back for the top spot in the NFC West Division. The Cardinals (2-4) must find a way to improve a defense that ranks near the bottom of the league in yards allowed (373.3 ypg) and is giving up 27.2 points per contest. On Sunday, Arizona was gashed for 437 yards and committed three turnovers during an ugly 34-13 road loss against Green Bay. 

Arizona trailed 24-0 late in the second quarter when QB Kyler Murray found Michael Wilson for an 18-yard touchdown reception. Trey McBride added a game-high 96 receiving yards on eight catches for the Cardinals, who committed 13 penalties for 100 yards. 

Los Angeles DE Joey Bosa (hip) was unable to suit up for Sunday’s victory and is listed as questionable for this game. The Chargers have not allowed an opponent to score more than 20 points this season, so the under is worth a look. The stronger play is on the Cardinals to bounce back with a home victory. Final Score Prediction, Arizona Cardinals win 23-17.