Chiefs vs 49ers Picks and Prediction – 10/20/2024

By: Dylan Hellebrand |

Last Updated: 10/14/2024 at 7:40 PM ET

Kansas City Chiefs at San Francisco 49ers 10/20/24 - NFL Picks & Predictions
Game Start: 10/20/2024, 8:25 PM UTC
Latest Odds: SF -1.5 ; O/U 46.5

Chiefs vs 49ers Prediction

On Sunday, the Kansas City Chiefs (5-0) face off against the San Francisco 49ers (3-3) at Levi’s Stadium in Santa Clara, California. Get our free NFL Picks all season long!

San Francisco comes into this matchup on a one-game winning streak, but has dropped three of their last five games. In a commanding 36-24 victory over the Seattle Seahawks, San Francisco 49ers' quarterback Brock Purdy showcased impressive skill by completing 18 of his 28 pass attempts. He racked up 255 yards through the air and delivered three touchdown passes, contributing significantly to the team's triumph. Throughout this season, Purdy has amassed a total of 1,629 passing yards. On the ground, running back Jordan Mason has been a force, accumulating 609 rushing yards. Meanwhile, wide receiver Jauan Jennings has proven to be a reliable target, bringing in 404 receiving yards for the team. Over their last five matchups, the 49ers' defense has allowed opponents to score an average of 22.2 points per game. Currently, San Francisco is neck and neck with the Seattle Seahawks at the top of the NFC West standings. As they prepare for their upcoming game against the Kansas City Chiefs, the 49ers aim to make significant defensive plays early in the contest, aware of the Chiefs' unstoppable offensive streak. On average, the 49ers put up 27 points each game, highlighting their potent scoring capability.

Kansas City enters this game on a five-game winning streak to start the season. In their impressive 26-13 victory over the New Orleans Saints, Kansas City Chiefs' quarterback, Patrick Mahomes, delivered an outstanding performance by completing 28 out of 39 passing attempts, accumulating a total of 331 yards. Through the current season, Mahomes has showcased his skill with a remarkable 1,235 passing yards. On the ground, running back Kareem Hunt has contributed significantly with 171 rushing yards, while wide receiver Rashee Rice has been a key player in the aerial attack, amassing 288 receiving yards for the team. As the Chiefs prepare for their next challenge against the San Francisco 49ers at Levi’s Stadium, they aim to replicate their recent success. Maintaining their undefeated streak is a priority, as they continue to assert their dominance in the league. Throughout this season, the Chiefs have been consistent in scoring, averaging 23.6 points per game.

Chiefs vs 49ers Pick Analysis

In Week 7 of the regular season, the San Francisco 49ers are set to face the Kansas City Chiefs, eager to seek redemption for their previous Super Bowl defeat against the same team. The Chiefs have been showcasing impressive performance, with an offense that consistently dominates, outscoring their rivals by an average margin of 6.6 points. The upcoming match promises to be a thrilling encounter as the 49ers aim to overturn their past loss against a formidable Kansas City offense. This will be a game to watch as both teams are looking to have elite games. Final Score Prediction, San Francisco 49ers win but fail to cover the spread, 27-26.

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